About the Lab

To ensure that cells function normally, tens of thousands of genes must be turned on or off together.  To do this, regulatory molecules – transcription factors, RNA binding proteins and non-coding RNAs – simultaneously control hundreds of genes.  The Gale-Hammell lab studies how the resulting gene networks function and how they can be compromised in human disease.  This includes an emphasis on developing novel tools for the statistical analysis of genomics data, developing novel algorithms for modeling the flow of signals through genetic pathways, and importantly, testing these models using the tools of molecular genetics.

One particular focus of the Gale-Hammell lab is to apply these novel statistical analysis methods to better understand how transposable elements are controlled in animal cells.  Transposons are viral-like parasites that lay dormant within our genomes, but have the capacity to hop into new genomic locations, causing mutations as they break the surrounding DNA sequence. Mounting evidence has implicated transposon activity in a host of human diseases, with particular evidence for activation in several neurodegenerative diseases, including Amyotrophic lateral sclerosis (ALS) and Fronto-Temporal Dementia (FTD).  By combining the power of systems-level, high-throughput data analysis with patient-derived ALS and FTD diseased tissue samples, the lab aims to better understand how transposons contribute to cell death and disease.

Molly Gale Hammell

Associate Professor

Transposable Elements; Amyotrophic Lateral Sclerosis (ALS); RNA biology; Small RNAs; Computational Genomics; Neurodegenerative Disease

External funding sources

We wish to acknowledge the following groups for providing us additional funding for our research.